Alert : Management Configuration Service failed to process agent configuration request

Hi,

We have 4 management servers. 2 in one datacenter A and other 2 in datacenter B.

We are receiving below alerts for both MS's in data center B.

Alert - Management Configuration Service failed to process agent configuration request

Alert Description :

Management Configuration Service failed to process agent configuration request. OpsMgr Management Configuration Service failed to process configuration request (Xml configuration file or management pack request) due to the following exception

Microsoft.EnterpriseManagement.ManagementConfiguration.DataAccessLayer.DataAccessException: Data access operation failed
at Microsoft.EnterpriseManagement.ManagementConfiguration.DataAccessLayer.DataAccessOperation.ExecuteSynchronously(Int32 timeoutSeconds, WaitHandle stopWaitHandle)
at Microsoft.EnterpriseManagement.ManagementConfiguration.CmdbOperations.CmdbDataProvider.GetManagementPack(Guid managementPackVersionDependentId)
at Microsoft.EnterpriseManagement.ManagementConfiguration.Engine.TracingConfigurationDataProvider.GetManagementPack(Guid managementPackVersionDependentId)
at Microsoft.EnterpriseManagement.ManagementConfiguration.Engine.AgentRequestProcessor.ProcessManagementPackRequest(ManagementPackRequestDescriptor requestDescriptor)
at Microsoft.EnterpriseManagement.ManagementConfiguration.Engine.AgentRequestProcessor.Execute()
at Microsoft.EnterpriseManagement.ManagementConfiguration.Engine.ThreadManager.ResponseThreadStart(Object state)
-----------------------------------
System.Data.SqlClient.SqlException (0x80131904): Timeout expired. The timeout period elapsed prior to completion of the operation or the server is not responding. ---> System.ComponentModel.Win32Exception (0x80004005): The wait operation timed out
at System.Data.SqlClient.SqlConnection.OnError(SqlException exception, Boolean breakConnection, Action`1 wrapCloseInAction)
at System.Data.SqlClient.TdsParser.ThrowExceptionAndWarning(TdsParserStateObject stateObj, Boolean callerHasConnectionLock, Boolean asyncClose)
at System.Data.SqlClient.TdsParser.TryRun(RunBehavior runBehavior, SqlCommand cmdHandler, SqlDataReader dataStream, BulkCopySimpleResultSet bulkCopyHandler, TdsParserStateObject stateObj, Boolean& dataReady)
at System.Data.SqlClient.SqlDataReader.TryHasMoreRows(Boolean& moreRows)
at System.Data.SqlClient.SqlDataReader.TryReadInternal(Boolean setTimeout, Boolean& more)
at System.Data.SqlClient.SqlDataReader.Read()
at Microsoft.EnterpriseManagement.ManagementConfiguration.CmdbOperations.ManagementPackGetOperation.ReadData(SqlDataReader reader)
at Microsoft.EnterpriseManagement.ManagementConfiguration.DataAccessLayer.ReaderSqlCommandOperation.SqlCommandCompleted(IAsyncResult asyncResult)
ClientConnectionId:57a4d28c-4acc-4ab4-9e39-9be9c445e8a2

Can anyone help me to understand issue and how we can avoid it.

Thanks.